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Ned Luke is an actor with a career spanning video games, television, film, and voice work, he has built a versatile resume through guest roles and recurring appearances on popular series.

Luke achieved widespread recognition for his iconic role as Michael De Santa in the 2013 blockbuster video game Grand Theft Auto V, providing both voice and motion capture performance for the retired bank robber turned family man. He reprised the character in Grand Theft Auto Online updates, including content as recent as 2025. His portrayal of the complex, midlife-crisis-stricken protagonist has become one of gaming's most celebrated performances.

His early credits include shows such as General Hospital, Renegade, NYPD Blue, and JAG. He also appeared in notable programs like Law & Order: Special Victims Unit, Boardwalk Empire, and Third Watch, often delivering memorable supporting performances in high-profile network television.

In film, Luke has contributed to projects including The Nutty Professor, On the Line, and the animated Rover Dangerfield, where he voiced Raffles. His work extends to additional credits in movies and TV movies, demonstrating consistent presence in both live-action and voice acting.